2010
- "Design, Synthesis and Operation of Small Molecules That Walk along Tracks", M von Delius, E M Geertsema, D A Leigh and D-T D Tang, J Am Chem Soc, 132, 16134-16145 (2010).
- "Synthesis, Structure, and Dynamic Properties of Hybrid Organic-Inorganic Rotaxanes", B Ballesteros, T B Faust, C-F Lee, D A Leigh, C A Muryn, R G Pritchard, D Schultz, S J Teat, G A Timco and R E P Winpenny, J Am Chem Soc, 132, 15435-15444 (2010).
- "Synthesis and Solid State Structure of a Hydrazone-Disulfide Macrocycle and its Dynamic Covalent Ring-Opening Under Acidic and Basic Conditions",
M von Delius, E M Geertsema, D A Leigh and A M Z Slawin, Org Biomol Chem, 8, 4617-4624 (2010).
[Selected as an OBC "Hot Article" 2010]
- "In Trap Fragmentation and Optical Characterization of Rotaxanes", A M Rijs, I Compagnon, A Silva, J S Hannam, D A Leigh, E R Kay and P Dugourd, Phys Chem Chem Phys, 12, 12556-12561 (2010).
- "Interlocked Molecules: Linking Rings Without Templates (N&Vs)" , J E Beves and D A Leigh, Nature Chem, 2, 708-710 (2010).
- "Ligand-Assisted Nickel-Catalysed sp3-sp3 Homocoupling of Unactivated Alkyl Bromides and its Application to the Active Template Synthesis of Rotaxanes", S M Goldup, D A Leigh, R T McBurney, P R McGonigal and A Plant, Chem Sci, 1, 383-386 (2010).
- "Nitrone [2]Rotaxanes: Simultaneous Chemical Protection and Electrochemical Activation of a Functional Group", D M D'Souza, D A Leigh, L Mottier, K M Mullen, F Paolucci, S J Teat and S Zhang, J Am Chem Soc, 132, 9465-9470 (2010).
- "Operation Mechanism of a Molecular Machine Revealed Using Time-Resolved Vibrational Spectroscopy",
M R Panman, P Bodis, D J Shaw, B H Bakker, A C Newton, E R Kay, A M Brouwer, W J Buma, D A Leigh and S Woutersen, Science, 328, 1255-1258 (2010).
Full Article. How it works.
[For highlights of this paper see: 'Molecular machine's movement turns out to be a dishonest gambling game', FOM, 4 June 2010; 'Motion of molecular machinery appears unfair', AllePersberichten (in Dutch), 4 June 2010.]
- "Controlled Hydrogen-Bond Breaking in a Rotaxane by Discrete Solvation", A M Rijs, N Sändig, M N Blom, J Oomens, J S Hannam, D A Leigh, F Zerbetto and W J Buma, Angew Chem Int Ed, 49, 3896-3900 (2010).
- "An Unusual Nickel−Copper-Mediated Alkyne Homocoupling Reaction for the Active-Template Synthesis of [2]Rotaxanes", J D Crowley, S M Goldup, N D Gowans, D A Leigh, V E Ronaldson and A M Z Slawin, J Am Chem Soc, 132, 6243-6248 (2010).
- "Diels-Alder Active-Template Synthesis of Rotaxanes and Metal-Ion-Switchable Molecular Shuttles", J D Crowley, K D Hänni, D A Leigh and A M Z Slawin, J Am Chem Soc, 132, 5309-5314 (2010).
- "Sequence Isomerism in [3]Rotaxanes", A-M L Fuller, D A Leigh and P J Lusby, J Am Chem Soc, 132, 4954-4959 (2010).
- "Improved Dynamics and Positional Bias with a Second Generation Palladium(II)-Complexed Molecular Shuttle", D A Leigh, P J Lusby, R T McBurney and M D Symes, Chem Commun, 46, 2382-2384 (2010).
- "A Synthetic Small Molecule That Can Walk Down a Track",
M von Delius, E M Geertsema and D A Leigh, Nature Chem, 2, 96-101 (2010).
Full Article.
News & Views.
How it works.
Featured on the front cover of Nature Chemistry issue 2, 2 (2010).
[For highlights of this paper see: 'Tiny Steps (N&Vs) ' S Otto, Nature Chem, 2, 75-76 (2010); 'Big Steps for Little Feet', Science, 327, 127 (2010); '"Two-legged" molecular walker takes a stroll' Chem World, 21 Dec 2009; 'Tiny molecular track walker' Chem & Eng News, 87(51), 34 (2009); 'Edinburgh motive force for NEMS' Compute Scotland, 21 Dec 2009. 'Двуногая молекула на (in Russian)' Remedium, 23 Dec 2009. '두 다리로 걷는 보행분자 ('Walking on two legs walking molecule'; in Korean)' GTNET, 23 Dec 2009. 'Tiny molecules walk the track' Science News, 12 Feb 2010. '두 다리로 걷는 보행분자 (in Korean)' HelloDD.com, 12 Feb 2010. '두 다리로 걷는 보행분자 ('Walking on two legs walking molecule'; in Korean)' Radar, 12 Feb 2010. 'Cutting-edge chemistry in 2010' Chemistry World, 21 Dec 2010.]
- "Two Axles Threaded Using a Single Template Site: Active Metal Template Macrobicyclic [3]Rotaxanes",
S M Goldup, D A Leigh, P R McGonigal, V E Ronaldson and A M Z Slawin, J Am Chem Soc, 132, 315-320 (2010).
[For a highlight of this paper see 'Templated Threading to [3]Rotaxanes' T M Swager and B Esser, Synfacts, 301 (2010)]
- "The Application of CuAAC Click Chemistry to Catenane and Rotaxane Synthesis",
K D Hänni and D A Leigh, Chem Soc Rev, 39, 1240-1251 (2010).
[Top 10 most highly accessed Chem Soc Rev article April 2010]
2009
- "Active Metal Template Synthesis of [2]Catenanes", S M Goldup, D A Leigh, T Long, P R McGonigal, M D Symes and J Wu, J Am Chem Soc, 131, 15924-15929 (2009).
- "Photoinduced Shuttling Dynamics of Rotaxanes in Viscous Polymer Solutions", D C Jagesar, S M Fazio, J Taybi, E Eiser, F G Gatti, D A Leigh and A M Brouwer, Adv Funct Mater, 19, 3440-3449 (2009).
- "AAA-DDD Triple Hydrogen Bond Complexes", B A Blight, A Camara-Campos, S Djurdjevic, M Kaller, D A Leigh, F M McMillan, H McNab and A M Z Slawin, J Am Chem Soc, 131, 14116-14122 (2009).
- "Conformational Flexibility of a Rotaxane Thread Probed by Electronic Spectroscopy in Helium Nanodroplets", S Smolarek, A M Rijs, J S Hannam, D A Leigh, M Drabbels and W J Buma, J Am Chem Soc, 131, 12902-12903 (2009).
- "Two-Dimensional Vibrational Spectroscopy of Rotaxane-Based Molecular Machines", P Bodis, M R Panman, B H Bakker, A Mateo-Alonso, M Prato, W J Buma, A M Brouwer, E R Kay, D A Leigh and S Woutersen, Acc Chem Res, 42, 1462-1469 (2009).
- "Rotaxane-Based Propeptides: Protection and Enzymatic Release of a Bioactive Pentapeptide", A Fernandes, A Viterisi, F Coutrot, S Potok, D A Leigh, V Aucagne and S Papot, Angew Chem Int Ed, 48, 6443-6447 (2009); published online as an Angewandte Chemie 'Hot' paper July 27 2009.
- "Active Metal Template Synthesis of Rotaxanes, Catenanes and Molecular Shuttles", J D Crowley, S M Goldup, A-L Lee, D A Leigh and R T McBurney, Chem Soc Rev, 38, 1530-1541 (2009).
- "Hybrid Organic-Inorganic Rotaxanes and Molecular Shuttles",
C-F Lee, D A Leigh, R G Pritchard, D Schultz, S J Teat, G A Timco and R E P Winpenny, Nature, 458, 314-318 (2009).
Full Article.
Nature Podcast.
[For highlights of this paper see: 'The Marriage of Inorganic and Organic Building Blocks for the Assembly of Rotaxanes' E K Brechin and L Cronin, Angew Chem Int Ed, 48, 6948-6949 (2009); 'Rotaxanes go hybrid' Chem & Eng News, 87(12), 11 (2009); 'Major leap for faster computers' BBC News, 19 March 2009; 'Combining nanomagnetics with molecular machines' Compute Scotland, 18 March 2009; 'Scientists make quantum leap in developing faster computers' Nanotechnology Now, 20 March 2009; 'Molecular scale technology used for quantum computers' New Electronics, 19 March 2009; 'Researchers tout molecular-scale devices for quantum computing' EE Times, 20 March 2009; 'Quantum computers moving closer' Singularity & Futurism, 19 March 2009; 'Major breakthrough for quantum computers announced' Daily Debrief, 19 March 2009; 'Major leap for faster computers' Digital Silence, 20 March 2009; 'Critical component of quantum computing discovered' Fudzilla, 22 March 2009; and others]
- "Getting Harder: Cobalt(III)-Template Synthesis of Catenanes and Rotaxanes", D A Leigh, P J Lusby, R T McBurney, A Morelli, A M Z Slawin, A R Thomson and D B Walker, J Am Chem Soc, 131, 3762-3771 (2009).
- "Stiff and Sticky in the Right Places: Binding Interactions in Isolated Mechanically Interlocked Molecules Probed by Mid-Infrared Spectroscopy", A M Rijs, I Compagnon, J Oomens, J S Hannam, D A Leigh and W J Buma, J Am Chem Soc, 131, 2428-2429 (2009).
- "Multistate Photo-Induced Relaxation and Photoisomerization Ability of Fumaramide Threads: A Computational and Experimental Study", P Altoe, N Haraszkiewicz, F G Gatti, P G Wiering, C Frochot, A M Brouwer, G Balkowski, D Shaw, S Woutersen, W J Buma, F Zerbetto, G Orlandi, D A Leigh and M Garavelli, J Am Chem Soc, 131, 104-117 (2009).
2008
- "An Ion-Pair Template for Rotaxane Formation and its Exploitation in an Orthogonal Interaction Anion-Switchable Molecular Shuttle", M J Barrell, D A Leigh, P J Lusby and A M Z Slawin, Angew Chem Int Ed, 47, 8036-8039 (2008).
- "Tuning Magnetic Properties Using Targeted Structural Distortion: New Additions to a Family of Mn6 Single-Molecule Magnets", L F Jones, M E Cochrane, B D Koivisto, D A Leigh, S P Perlepes, W Wernsdorfer and E K Brechin, Inorg Chim Acta, 361, 3420-3426 (2008).
- "Gold(I)-Template Catenane and Rotaxane Synthesis",
S M Goldup, D A Leigh, P J Lusby, R T McBurney and A M Z Slawin, Angew Chem Int Ed, 47, 6999-7003 (2008).
Featured on the front cover of Angewandte Chemie issue 37, 47 (2008).
['Molecule-of-the-Week' notjustanotherchemblog, 30 August, 2008]
- "An Ammonium/bis-ammonium Switchable Molecular Shuttle", D A Leigh and A R Thomson, Tetrahedron, 64, 8411-8416 (2008).
- "Cadiot-Chodkiewicz Active Template Synthesis of Rotaxanes and Switchable Molecular Shuttles with Weak Intercomponent Interactions", J Berná, S M Goldup, A-L Lee, D A Leigh, M D Symes, G Teobaldi and F Zerbetto, Angew Chem Int Ed, 47, 4392-4396 (2008).
- "Active Template Synthesis of Rotaxanes and Molecular Shuttles with Switchable Dynamics by Four-component Pd(II)-promoted Michael Additions", S M Goldup, D A Leigh, P J Lusby, R T McBurney and A M Z Slawin, Angew Chem Int Ed, 47, 3381-3384 (2008).
- "Shaping of a Conformationally Flexible Molecular Structure for Spectroscopy", A M Rijs, B O Crews, M S de Vries, J S Hannam, D A Leigh, M Fanti, F Zerbetto and W J Buma, Angew Chem Int Ed, 47, 3174-3179 (2008).
- "Three State Redox-Active Molecular Shuttle That Switches in Solution and on a Surface",
G Fioravanti, N Haraszkiewicz, E R Kay, S M Mendoza, C Bruno, M Marcaccio, P G Wiering, F Paolucci, P Rudolf, A M Brouwer and D A Leigh, J Am Chem Soc, 130, 2593-2601 (2008).
[For a highlight of this paper see 'Applied Chemistry Highlights' N P Freestone, Chem & Ind, May 2008, 26-28.]
- "A Chemically-Driven Molecular Information Ratchet",
M Alvarez-Pérez, S M Goldup, D A Leigh and A M Z Slawin, J Am Chem Soc, 130, 1836-1838 (2008).
[For a highlight of this paper see 'Energy in Motion' D Castelvecchi, Science News, 173(8), 120-121 (2008); 'Free Lunch (at a Cost)' Sci Amer, p 65, May 2009.]
- "Beyond Switches: Rotaxane- and Catenane-Based Synthetic Molecular Motors", E R Kay and D A Leigh, Pure Appl Chem, 80, 17-29 (2008).
- "Chemically Driven Artificial Molecular Machines", J D Crowley, E R Kay and D A Leigh in Intelligent Materials, M Shahinpoor and H-J Schneider (eds), p. 1-47, RSC, Cambridge (2008).
2007
- "Structural Dynamics of Rotaxanes Studied by Infrared Photon Echo Spectroscopy", S Yeremenko, O F A Larsen, P Bodis, W J Buma, J S Hannam, D A Leigh and S Woutersen, Springer Series in Chemical Physics, 88, 430-432 (2007).
- "A Switchable Palladium-Complexed Molecular Shuttle and Its Metastable Positional Isomers", J D Crowley, D A Leigh, P J Lusby, R T McBurney, L-E Perret-Aebi, C Petzold, A M Z Slawin and M D Symes, J Am Chem Soc, 129, 15085-15090 (2007).
- "A Metal-Complex-Tolerant CuAAC 'Click' Protocol Exemplified through the Preparation of Homo- and Mixed-Metal-Coordinated [2]Rotaxanes", D González Cabrera, B D Koivisto and D A Leigh, Chem Commun, 4218-4220 (2007).
- "[2]Rotaxanes through Palladium Active-Template Oxidative Heck Cross-Couplings", J D Crowley, K D Hänni, A-L Lee and D A Leigh, J Am Chem Soc, 129, 12092-12093 (2007).
- "Catalytic 'Active-Metal' Template Synthesis of [2]Rotaxanes, [3]Rotaxanes and Molecular Shuttles, and Some Observations on the Mechanism of the Cu(I)-Catalyzed Azide-Alkyne 1,3-Cycloaddition", V Aucagne, J Berná, J D Crowley, S M Goldup, K D Hänni, D A Leigh, P J Lusby, V E Ronaldson, A M Z Slawin, A Viterisi and D B Walker, J Am Chem Soc, 129, 11950-11963 (2007).
- "A Catalytic Palladium Active-Metal Template Pathway to [2]Rotaxanes",
J Berná, J D Crowley, S M Goldup, K D Hänni, A-L Lee and D A Leigh, Angew Chem Int Ed, 46, 5709-5713 (2007).
[For a highlight of this paper see 'Palladium-Catalyzed Synthesis of Rotaxanes' T M Swager and R M Moslin, Synfacts, 11, 1158 (2007).]
- "Heterovibrational Interactions, Cooperative Hydrogen Bonding and Vibrational Energy Relaxation Pathways in a Rotaxane", P Bodis, R Timmer, S Yeremenko, W J Buma, J S Hannam, D A Leigh and S Woutersen, J Phys Chem C, 111, 6798-6804 (2007).
- "The Effect of Solvent Upon Molecularly Thin Rotaxane Film Formation", A A Farrell, E R Kay, G Bottari, D A Leigh and S P Jarvis, Appl Surf Sci, 253, 6090-6095 (2007).
- "One Template, Multiple Rings: Controlled Iterative Addition of Macrocycles onto a Single Binding Site Rotaxane Thread", A-M L Fuller, D A Leigh and P J Lusby, Angew Chem Int Ed, 46, 5015-5019 (2007); published online as an Angewandte Chemie 'VIP' paper May 25 2007.
- "A Rotaxane Mimic of the Photoactive Yellow Protein Chromophore Environment: Effects of Hydrogen Bonding and Mechanical Interlocking on a Coumaric Amide Derivative", J Berná, A M Brouwer, S M Fazio, N Haraszkiewicz, D A Leigh and C M Lennon (neé Keaveney), Chem Commun, 1910-1912 (2007).
- "Coumaric Amide Rotaxanes: Effects of Hydrogen Bonding and Mechanical Interlocking on the Photochemistry and Photophysics", A M Brouwer, S M Fazio, N Haraszkiewicz, D A Leigh and C M Lennon (neé Keaveney), Photochem. Photobiol. Sci., 6, 480-486 (2007).
- "A Molecular Information Ratchet"
V Serreli, C-F Lee, E R Kay and D A Leigh, Nature, 445, 523-527 (2007).
Full Article.
Making the Paper.
Nature Nanotech N&V's.
How it Works.
[For highlights of this paper see 'Knowledge is power!'(N&V's) A P Davis, Nature Nanotech, 2, 135-136 (2007); A demon of a device Nature (news), 31 Jan 2007; Molecular machines: Facing their demons Nature Nanotech, 2 Feb 2007; Maxwell's demon tamed Physicsweb, 31 Jan 2007; Demon ratchets up nanotech revolution Chemistry World, 31 Jan 2007; Cutting-edge chemistry in 2007 Chemistry World, 18 Dec 2007; Scientists build nanomachine envisaged 150 years ago Scientific American,31 Jan 2007; Demonic chemistry Intute, 2 Feb 2007; Tiny engine boosts nanotech hopes BBC news, 1 Feb 2007; 1867 nanomachine now reality CNN, 2 Feb 2007; Laws of Nature survive attack by Nano Demon Daily Telegraph, 2 Feb 2007; Opening the door to Maxwell's Demons The Scotsman, 3 Feb 2007; Maxwell's devilishly clever idea moves closer to reality The Herald, 1 Feb 2007; Scientists build nanomachine envisaged 150 years ago Washington Post, 31Jan 2007; Reviving a 19thcentury nanomachine The Australian,1 Feb 2007; Scientists build Maxwell's demon Daily News (India), 1 Feb2007; Nanomachines: Maxwell's Demon becomes a reality Xinhua News(China), 1 Feb 2007; Scientiststake 150 years to build nanomachine MacUser,1 Feb 2007; 150-year-old idea inspiresnanomachine MSNBC, 31 Jan 2007; A fundamentally new type ofmotor-mechanism for artificial nanomachines Nanowerk News, 31 Jan 2007; Maxwell's Demon Created by Scottish ScientistsZpenergy, 1 Feb 2007; Edinburgh scientists craftmicroscopic nanomachines engadget, 1 Feb 2007; Chemists take 150 years tobuild nanomotor ABC news, 1 Feb2007; 140 years later, James ClerkMaxwell's demon materializes SooToday,1 Feb 2007; Un nanomotore permicromacchine il diavoletto di Maxwell diventa realtá(in Italian) La Repubblica, 1 Feb 2007; Gesetzestreue Dämonen(in German)Telepolis, 1 Feb 2007; Maxwellsmoleculaire duveltje(in Dutch) C2W,1 Feb 2007; Демон позапрошлого веканарушил равновесие круглых молекул(in Russian) Membrana, 2 Feb 2007; 现代版麦克斯韦思想实验(in Chinese) Nature Asia-Pacific, 1Feb 2007; El tridente informativo del demonio de Maxwell (in Spanish) Anales de Química, 103, 74, (2007); Cientificos Construyen Primer Motor Basado En NanoTecnologia(in Spanish) Terra, 5 Feb2007; La Diabolica Nanomacchina del Signor Maxwell (in Italian) >Next Station, 4 Feb2007; Dalla Scozia il Micromotore che Muovera le Nanomacchine’ (in Italian) La Stampa, 1 Feb2007; Cientistas dão mais um passo em pesquisas da nanotecnologia (in Portuguese) swissinfo, 9 Feb2007; and others]
- "Amide-based molecular shuttles (2001-2006)", J Berná, G Bottari, D A Leigh and E M Pérez, Pure Appl. Chem., 79, 39-54 (2007).
- "Extremely Strong and Readily Accessible AAA-DDD Triple Hydrogen Bond Complexes",
S Djurdjevic, D A Leigh, H McNab, S Parsons, G Teobaldi and F Zerbetto, J Am Chem Soc, 129, 476-477 (2007).
[For a highlight of this paper see 'Really Strong Triple H-Bonding',Chem & Eng News,85(2), 44 (2007).]
- "Synthetic Molecular Motors and Mechanical Machines", E R Kay, D A Leigh and F Zerbetto, Angew Chem Int Ed, 46, 72-191 (2007). [Most-accessed 2007 Angewandte Chemie article Dec 2006-Nov 2007; Most-cited 2007 Angewandte Chemie article as of 9 March 2009 (source: Angewandte Chemie)]
2006
- "Self-organization of Nano-lines and Dots Triggered by a Local Mechanical Stimulus",
F Biscarini, M Cavallini, R Kshirsagar, G Bottari, D A Leigh, S León and F Zerbetto, Proc Natl Acad Sci USA, 103, 17650-17654 (2006).
[For a highlight of this paper see 'Self-assembly: Push to organize', A LChun, Nature Nanotech, 2, 15 (2007)]
- "Switchable Dual Binding Mode Molecular Shuttle", D A Leigh and A R Thomson, Org Lett, 8, 5377-5379 (2006).
- "Adsorption of Fumaramide [2]rotaxane and its Components on a Solid Substrate: A Coverage-dependent Study", C M Whelan, F G Gatti, D A Leigh, S Rapino, F Zerbetto and P Rudolf, J Phys Chem B, 110, 17076-17081 (2006).
- "Chemoselective Formation of Successive Triazole Linkages in One Pot: 'Click-Click' Chemistry", V Aucagne and D A Leigh, Org Lett, 8, 4505-4507 (2006). [Top-ten most-requested Chemistry journal article on SciFinder/SciFinder Scholar/STN/ChemAbs in 4th quarter 2006, CAS Science Spotlight]
- "Surface Enhanced Second Harmonic Generation from Macrocycle, Catenane and Rotaxane Thin Films: Experiments and Theory", I Arfaoui, V Bermúdez, G Bottari, C De Nadai, J-P Jalkanen, F Kajzar, D A Leigh, M Lubomska, S M Mendoza, J Niziol, P Rudolf and F Zerbetto, J Phys Chem B, 110, 7648-7652 (2006).
- "Lighting Up Nanomachines", E R Kay and D A Leigh, Nature, 440, 286-287 (2006).
- "Dynamic Chirality: Molecular Shuttles and Motors", D A Leigh and E M Pérez, in Supramolecular Chirality, M Crego-Calama & D N Reinhoudt (eds.), Topics Curr Chem, 265, 185-208 (2006).
- "Beyond Switches: Ratcheting a Particle Energetically Uphill with a Compartmentalized Molecular Machine", M N Chatterjee, E R Kay and D A Leigh, J Am Chem Soc, 128, 4058-4073 (2006). [15th most-cited J Am Chem Soc article in 2006]
- "Catalytic "Click" Rotaxanes: A Substoichiometric Metal-Template Pathway to Mechanically Interlocked Architectures", V Aucagne, K D Hänni, D A Leigh, P J Lusby and D B Walker, J Am Chem Soc, 128, 2186-2187 (2006).
- "An Allosterically Regulated Molecular Shuttle", D S Marlin, D González Cabrera, D A Leigh and A M Z Slawin, Angew Chem Int Ed, 45, 1385-1390 (2006).
- "Rotaxanes of Cyclic Peptides", V Aucagne, D A Leigh, J S Lock and A R Thomson, J Am Chem Soc, 128, 1784-1785 (2006).
- "Self-organization of Rotaxane Thin Films into Spatially Correlated Nanostructures: Morphological and Structural Aspects", J-F Moulin, J C Kengne, R Kshirsagar, M Cavallini, F Biscarini, S León, F Zerbetto, G Bottari and D A Leigh, J Am Chem Soc, 128, 526-532 (2006).
- "Complexation-Induced Translational Isomerism: Shuttling through Stepwise Competitive Binding", D S Marlin, D González Cabrera, D A Leigh and A M Z Slawin, Angew Chem Int Ed, 45, 77-83 (2006).
[For highlights of this paper see: ' Peptides Trapped On A Thread', Chem & Eng News, Jan 25 (2006)]